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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Updated: Jun 24, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Functional proteomics to exploit genome sequences.

A D Strosberg1

  • 1Hybrigenics SA, Paris, France. adstrosberg@hybrigenics.fr

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|February 13, 2002
PubMed
Summary
This summary is machine-generated.

Genomic sequencing advances understanding of cell function by analyzing proteins. This study explores the progression from genome to proteome, focusing on protein-protein interactions within the cellular interactome.

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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Area of Science:

  • Molecular Biology
  • Genomics
  • Proteomics

Background:

  • Genome sequencing has opened new avenues for understanding cellular functions, both normal and pathological.
  • Proteins are central to life's molecular mechanisms, including growth, reproduction, and cell interactions.
  • Understanding these protein roles is key to describing integrated biological systems.

Purpose of the Study:

  • To outline the evolution of knowledge from genomics to functional proteomics.
  • To emphasize a global approach to studying protein-protein interactions.
  • To describe the cellular interactome.

Main Methods:

  • Review of scientific literature on genomics and proteomics.
  • Analysis of protein functions in cellular mechanisms.
  • Exploration of methodologies for mapping protein-protein interactions.

Main Results:

  • The progression from genome to proteome analysis provides a comprehensive view of cellular biology.
  • Global analysis of protein-protein interactions is crucial for understanding the cellular interactome.
  • This approach integrates diverse biological data for a systems-level understanding.

Conclusions:

  • The study highlights the critical role of proteins in cellular function and biological systems.
  • A systems biology approach, focusing on the interactome, is essential for advancing our understanding.
  • Future research should continue to integrate genomic and proteomic data for deeper biological insights.