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Published on: January 13, 2017
Total synthesis of (+/-) tanikolide
1Department Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Munich, Germany.
Natural Product Letters
|February 13, 2002
Abstract:
The natural polyketide (+/-)-tanikolide (1) was prepared in eight steps starting from hex-5-enol. Key steps in this synthesis are a Sharpless dihydroxylation and a Grignard reaction between an alkyl halogenide and a ketone. The lactonization occurred spontaneously during the oxidation of the primary alcohol function to the carboxy group.
