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T-cell differentiation: MHC class I's sweet tooth lost on maturity
1Department of Immunology, IMM1, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. gascoigne@scripps.edu
The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during thymocyte differentiation. Two recent papers have shown that this glycosylation changes the avidity of the interaction between CD8 and MHC class I proteins, potentially altering signalling thresholds in thymocyte differentiation.
The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during thymocyte differentiation. Two recent papers have shown that this glycosylation changes the avidity of the interaction between CD8 and MHC class I proteins, potentially altering signalling thresholds in thymocyte differentiation.