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Updated: Aug 18, 2026
13:10
Analysis of DNA Double-strand Break (DSB) Repair in Mammalian Cells
Published on: September 8, 2010
Checkpoints: how to flag up double-strand breaks
Thomas Caspari1, Antony M Carr
1Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RR, UK.
Current Biology : CB
|February 13, 2002
Abstract:
How checkpoint pathways recognise double-strand breaks has long been a mystery. Recent studies have found that two distinct checkpoint protein complexes associate independently with chromatin at the sites of DNA damage. Why do two distinct mechanisms recognise strand lesions, and what does this tell us about the checkpoint pathways?
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