Automatic evaluation of arterial diameter variation from vascular echographic images

An automatic procedure for accurate arterial diameter evaluation from B-mode images obtained by diagnostic ultrasound systems is presented. It is used for measuring brachial artery dilation following reactive hyperemia induced by forearm ischemia, which is an appropriate parameter to study endothelial function in humans. B-mode images obtained from the diagnostic ultrasound system are acquired on a personal computer as grey intensity fields (pixels). A completely automatic algorithm is then applied and the artery walls are identified by two discrete sets of points. Artery diameter is evaluated by parabolic least-square approximation. The accuracy and extensive range of applicability of the diameter evaluation procedure were demonstrated both by preliminary analytic test cases and in vivo analyses. Reproducibility of the diameter estimate was assessed by in vivo measurements. The proposed procedure permits fast and accurate analysis of large amounts of data, because it requires no action by the operator. It thus represents a valuable tool for assessment of endothelium-dependent vasodilation, especially in large, multicentric clinical trials.