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Updated: Oct 2, 2026

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
A model for odour thresholds
Michael H Abraham1, Joëlle M R Gola, J Enrique Cometto-Muniz
1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. m.h.abraham@ucl.ac.uk
Abstract:
Odour detection thresholds, that we have previously obtained, have been analysed by a general equation for selective transport. It is shown that such selective transport can account for some 77% of the total effect. The remainder is due to a specific size effect, that might involve odour-binding proteins, and a specific effect for aldehydes and carboxylic acids. Our analysis raises the question of whether selective transport is physically separable from the specific effects of receptor activation. The model predicts a chemical cut-off in odour detection along any homologous series.

