Related Experiment Video
Updated: Aug 13, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Non-T(H)1 cytokines are augmented systematically early in Guillain-Barré syndrome
Rayomand Press1, V Ozenci, M Kouwenhoven
1Division of Neurology, Neuroimmunology Unit, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. rayomand.press@neurotec.ki.se
Abstract:
The T(H)1 vs non-T(H)1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor alpha-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.
More Related Videos
07:30A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
09:01Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020