Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Within-meal gut feedback signaling.

T H Moran1, E E Ladenheim, G J Schwartz

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. tmoran@jhmi.edu

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
|February 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mapping and targeted viral activation of pancreatic nerves in mice reveal their roles in the regulation of glucose metabolism.

Nature biomedical engineering·2022
Same author

Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation.

Pediatric nephrology (Berlin, Germany)·2019
Same author

Effects of meal composition on postprandial incretin, glucose and insulin responses after surgical and medical weight loss.

Obesity science & practice·2016
Same author

Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene.

Translational psychiatry·2015
Same author

Pharmacokinetics, Pharmacodynamics, and Safety of Lisinopril in Pediatric Kidney Transplant Patients: Implications for Starting Dose Selection.

Clinical pharmacology and therapeutics·2015
Same author

Palatable food avoidance and acceptance learning with different stressors in female rats.

Neuroscience·2013

Signals from the gut, including cholecystokinin (CCK), help end meals by influencing the brain. Blocking these signals increases meal size, showing their importance in appetite regulation.

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Physiology

Background:

  • Meals stimulate multiple gastrointestinal sites, initiating actions and feedback signals for meal termination.
  • Gastric emptying is rapid, moving nutrients to the intestine where they trigger responses.

Purpose of the Study:

  • To investigate the role of gastrointestinal feedback signals in meal termination.
  • To understand how vagal afferent fibers and brain-gut peptides contribute to satiety.

Main Methods:

  • Monitoring electrophysiological activity of gastric and duodenal vagal afferent fibers.
  • Measuring the release of brain-gut peptides like cholecystokinin (CCK).
  • Assessing meal size after blocking or eliminating feedback signals.

Related Experiment Videos

Main Results:

  • Nutrients in the stomach and duodenum activate vagal afferent fibers.
  • Duodenal nutrients stimulate CCK release, which modulates vagal afferent fiber activity.
  • Eliminating these feedback signals leads to larger meal sizes.

Conclusions:

  • Vagal afferent fibers and gut peptides like CCK are crucial for signaling meal termination.
  • These feedback mechanisms play a significant role in regulating appetite and food intake.