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Updated: Oct 2, 2026
A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Feasibility of nitric oxide administration by oxygen hood in neonatal pulmonary hypertension
Namasivayam Ambalavanan1, Elaine St John, Waldemar A Carlo
1Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 35249-6098, USA.
Objective:
To test the hemodynamic efficacy and feasibility of nitric oxide (NO) administration by oxygen hood in neonatal pulmonary hypertension.
Study Design:
A double-hood apparatus was used in which a combination of NO, O(2), and N(2) was introduced into the inner hood and suctioned from the outer hood. Chronically instrumented non-intubated piglets were exposed to 10% O(2) (hypoxia; n=8) or group B streptococci infusion (GBS; n=5) to produce pulmonary hypertension and were then exposed to 20 ppm NO.
Results:
NO decreased (>50%) pulmonary artery pressure and vascular resistance in both hypoxia- and GBS-induced pulmonary hypertension, with minimal effects on systemic arterial pressure and cardiac output. NO administration could be performed without detectable environmental leakage.
Conclusion:
Hood NO administration is feasible and shows hemodynamic efficacy in neonatal piglets with pulmonary hypertension.
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