Related Experiment Video
Updated: Jul 17, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
The regulation and function of the Id proteins in lymphocyte development
1Division of Biology, 0366, University of California at San Diego, La Jolla, CA 92093, USA. r3@biomail.ucsd.edu
Abstract:
Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.
Related Concept Videos
Master Transcription Regulators
Regulation of the Unfolded Protein Response
The JAK-STAT Signaling Pathway
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

