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Updated: Aug 10, 2026
Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines
Published on: September 10, 2014
Second-line treatment of ovarian cancer with single-agent gemcitabine
1Cleveland Clinic Foundation, Cleveland, OH 44195, USA. markmam@ccf.org
Abstract:
Single-agent gemcitabine has been examined in several phase II trials in platinum- and paclitaxel-resistant advanced ovarian cancer. In this population, where patients are often heavily pretreated prior to the administration of gemcitabine, an acceptable dose and schedule is 800 to 1,000 mg/m(2) weekly for 3 weeks, followed by a 1-week rest. The anticipated objective response rate in the platinum/taxane-resistant population is approximately 15%. This level of activity (confirmed in several phase II trials), and the generally favorable toxicity profile for gemcitabine in this group of patients, leads to the conclusion that single-agent gemcitabine is a reasonable second-line treatment option in previously treated women with advanced ovarian cancer.
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