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Updated: Aug 14, 2026
A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
[Intracorneal silicone oil deposits]
N Ardjomand1, E M Haller-Schober, J Faulborn
1Universitäts-Augenklinik, Karl-Franzens-Universität, Auenbruggerplatz 4, 8036 Graz, Osterreich. navid.ardjomand@kfunigraz.ac.at
Background:
A patient with intraocular silicone oildeposits underwent paracentral corneal incision but the corneal sutures were never removed and 7 years later a perforating corneal transplantation was performed due to corneal opacification.
Methods:
The corneal button was fixed in 10% buffered paraformaldehyde, embedded in celloidin and sections 200 microns thick were cut and stained with van Gieson. Some of these sections were embedded in paraffin and 5 microns thick sections were cut.
Results:
Celloidin sections showed intrastromal silicone oil droplets located adjacent to defects in Descemets' membrane and corneal sutures but the endothelial cells contained no silicone oil droplets.
Conclusion:
Silicone oil can penetrate the corneal stroma in cases of defects in Descemets' membrane.
