Related Experiment Video
Updated: Oct 2, 2026

Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
Published on: December 8, 2023
[Diagnosis and therapy of LASIK-induced neurotrophic epitheliopathy]
Abstract:
Laser in situ keratomileusis (LASIK) has emerged as the standard surgical procedure for the correction of refractive errors and in the last years a lot of experience has been gained. Consequently, the amount of intraoperative, early and late postoperative complications have significantly decreased. Keratitis punctata superficialis and dry eye symptoms are the most frequent postoperative complications. A decreased corneal sensitivity attributable to the cutting of the corneal sensory nerves has been described after LASIK. In addition pathological tear secretion tests and typical dry eye symptoms have been reported. Until know it has not been completely evaluated, if these symptoms are a combination of the dry eye disease and LASIK-induced symptoms or if they are due to an independent LASIK complication, the so-called LASIK-induced neurotrophic epitheliopathy. Independently of the incompletely understood etiology, much care and a sufficient therapy with artificial tears should be applied to such patients. To increase the comfort of LASIK, adequate intra- and postoperative treatment is necessary to enhance the patient satisfaction.

