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Subungual perineurioma: a peculiar location
1Nail Disease Centre, 42, rue des Serbes, 06400 Cannes, France. baran.r@club-internet.fr
The British Journal of Dermatology
|February 14, 2002
Summary
This study details the first reported case of subungual perineurioma, a rare tumor under the nail, presenting as finger clubbing. The tumor unexpectedly showed diffuse CD34 expression, complicating diagnosis.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Pathology
Background:
- Perineuriomas are rare tumors originating from peripheral nerve sheath cells.
- Subungual tumors are uncommon, and perineurioma in this location is exceptionally rare.
- Finger clubbing is typically associated with pulmonary or cardiac conditions.
Observation:
- A unique case of subungual perineurioma presenting as unilateral finger clubbing is described.
- Clinical presentation mimicked other conditions, highlighting diagnostic challenges.
- Histological examination revealed a myxoid tumor morphology.
Findings:
- The subungual tumor unexpectedly showed diffuse CD34 expression.
- This finding necessitates careful consideration of differential diagnoses.
- Distinguishing perineurioma from other myxoid soft tissue tumors expressing CD34 is crucial.
Implications:
- This case expands the clinical spectrum of perineurioma.
- Highlights the importance of considering rare tumors in unusual presentations.
- Emphasizes the utility of immunohistochemistry in differentiating soft tissue tumors.