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Related Experiment Videos

Sclerosing perineuriomas affecting bilateral hands.

H-Y Huang1, M-T Sung

  • 1Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University, 123, Ta-Pei Road, Niao-Sung, Kaohsiung Hsien, Taiwan, ROC.

The British Journal of Dermatology
|February 14, 2002
PubMed
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Sclerosing perineurioma, a rare tumor, typically presents as a solitary lesion. This case report details a 16-year-old boy with two distinct sclerosing perineuriomas, challenging the notion of solitary presentation.

Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Sclerosing perineurioma is a rare variant of perineurioma, characterized by hyalinization.
  • It commonly affects adolescents and young adults, typically presenting as solitary nodules on the hands.

Observation:

  • A 16-year-old male presented with two distinct sclerosing perineuriomas: one on the right palm and another on the left index finger.
  • Neither lesion was associated with neurofibromatosis stigmata.
  • Histopathological examination revealed characteristic cellular morphology and extensive stromal hyalinization in both tumors.

Findings:

  • Microscopic analysis showed small epithelioid and plump spindle cells in various growth patterns within a hyalinized stroma.
  • Immunohistochemistry confirmed strong epithelial membrane antigen (EMA) reactivity and negative staining for S-100 and neurofilament.

Related Experiment Videos

  • Ultrastructural examination supported perineurial cell differentiation in both lesions.

    • Implications:

    • This case demonstrates that sclerosing perineurioma can present as multiple lesions, expanding the known clinical spectrum.
    • It underscores the importance of considering multiple lesions in the differential diagnosis of hand nodules in young individuals.
    • Further research may elucidate the etiology and behavior of multifocal sclerosing perineuriomas.