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Related Experiment Videos

Recent progress and problems in animal cloning.

Y Tsunoda1, Y Kato

  • 1Laboratory of Animal Reproduction, College of Agriculture, Kinki University, Nara, 631-8505, Japan. tsunoda@nara.kindai.ac.jp

Differentiation; Research in Biological Diversity
|February 14, 2002
PubMed
Summary

Mammalian somatic cell nuclear transfer enables whole individual creation. However, animal cloning faces challenges like stillbirths and abnormalities, impacting its application in agriculture and human medicine.

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Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Biotechnology

Background:

  • Mammalian somatic cell nuclei can be reprogrammed to form complete organisms via nuclear transfer into enucleated oocytes.
  • Nuclear transfer technology offers potential applications in livestock improvement, conservation of endangered species, and human assisted reproduction.

Purpose of the Study:

  • To review the current status and challenges of animal cloning.
  • To explore the potential applications of nuclear transfer technology in human medicine.

Main Methods:

  • Review of existing literature on somatic cell nuclear transfer in mammals.
  • Analysis of reported outcomes and abnormalities in cloned animals.

Main Results:

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  • Over 200 calves produced via nuclear transfer in Japan since 1998, with a high mortality rate (stillbirths or early death).
  • Observed morphologic abnormalities in cloned calves and embryonic stem cell-derived mice.

    • Conclusions:

    • Significant challenges remain in animal cloning, including high mortality and developmental abnormalities.
    • Further research is needed to overcome these hurdles for successful application in agriculture and human medicine.