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Related Experiment Videos

How infection can trigger autoimmunity.

G R Burgio, A G Ugazio

    Infection
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Infections can trigger autoimmune diseases by disrupting immune tolerance. Pathogen exposure may impair self-non-self discrimination or mimic self-antigens, leading to autoimmune reactions.

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    Area of Science:

    • Immunology
    • Autoimmunity
    • Infectious Diseases

    Background:

    • The link between infection and autoimmunity is a complex area of research.
    • Understanding immunologic tolerance is crucial for deciphering autoimmune disease development.
    • Recent advances provide new insights into these interactions.

    Purpose of the Study:

    • To discuss the role of infection in autoimmunity development.
    • To explore mechanisms by which infectious agents may trigger autoimmune responses.
    • To evaluate clinical conditions based on these pathogenetic concepts.

    Main Methods:

    • Review of recent advances in immunologic tolerance.
    • Analysis of proposed pathogenetic mechanisms of infection-induced autoimmunity.

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  • Evaluation of clinical conditions through the lens of these mechanisms.

    • Main Results:

    • Infectious agents can impair self-non-self discrimination, potentially causing generalized autoimmunity.
    • Infectious agents can present self-determinants immunogenically or uncover sequestered antigens, potentially causing selective autoimmunity.
    • Personal factors interact with infection and autoimmunity.

    Conclusions:

    • Infection is a significant factor in the development of autoimmune diseases.
    • Two primary mechanisms explain how infections can lead to autoimmunity: direct immune damage and molecular mimicry.
    • These mechanisms help explain diverse autoimmune conditions and highlight the role of host factors.