Related Experiment Video
Updated: Aug 28, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Hyperandrogenism in adolescents
1Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital of Pittsburgh, Pennsylvania 15213, USA.
Abstract:
Signs and symptoms of excessive androgen secretion (hyperandrogenism) in adolescent and adult women include hirsutism, severe acne, and irregular menses. Because of the clinical features associated with hyperandrogenism, male adolescents do not usually present with signs or symptoms of androgen excess. This chapter focuses on causes of hyperandrogenism in adolescents, especially adolescent girls, including disorders of steroidogenesis, gonadal dysgenesis, Cushing's syndrome, tumors, and glucocorticoid resistance. Because polycystic ovary syndrome is discussed thoroughly in another chapter, it is not included. Brief discussions of androgen metabolism and steroidogenesis are followed by particulars of specific disorders. The chapter concludes with suggestions about differential diagnoses.
Related Concept Videos
Hormones of the Adrenal Glands
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Testosterone: Functions and Regulation
Signs of Puberty
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and lactation.
Cognitive Development During Adolescence

