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Mutation, specialization, and hypersensitivity in highly optimized tolerance.

Tong Zhou1, J M Carlson, John Doyle

  • 1Department of Physics, University of California, Santa Barbara, CA 93106, USA.

Proceedings of the National Academy of Sciences of the United States of America
|February 14, 2002
PubMed
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This study models evolution using lattice percolation, showing that Darwinian selection naturally produces Highly Optimized Tolerance (HOT). Organisms evolve density-robustness trade-offs, mimicking biological evolution.

Area of Science:

  • Evolutionary biology
  • Theoretical biology
  • Complex systems

Background:

  • Evolutionary processes drive biological complexity and robustness.
  • Understanding the mechanisms linking selection to robustness is crucial.

Purpose of the Study:

  • To introduce a novel model of evolution using percolation lattice models.
  • To investigate how Darwinian mechanisms can lead to Highly Optimized Tolerance (HOT).

Main Methods:

  • Representing competing organisms as sites on a percolation lattice.
  • Defining fitness based on remaining occupied sites after cluster removal.
  • Simulating mutation and selection processes.

Main Results:

  • High-fitness individuals exhibit a trade-off between density and robustness to loss.

Related Experiment Videos

  • Cellular barrier patterns emerge, preventing large cascading losses.
  • The model naturally generates Highly Optimized Tolerance (HOT) through Darwinian mechanisms.

    • Conclusions:

    • Darwinian evolution can naturally produce Highly Optimized Tolerance (HOT).
    • Percolation models offer a powerful abstraction for studying evolutionary features.
    • The model's outputs show striking similarities to real biological evolution at multiple scales.