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New and antifungal xanthones from Calophyllum caledonicum

Cécile Morel1, Denis Séraphin, Agnès Teyrouz

  • 1SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la santé, 16, Bd Daviers, Angers, France.

Planta Medica
|February 14, 2002
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...