Inverted transitional cell papilloma of the uterine cervix

A rare case of inverted transitional cell papilloma of the uterine cervix in a 54-year-old woman is described. A polypoid nodule 8 mm in diameter showed histologic features similar to those of urinary tract inverted papilloma. It contained inverted anastomosing epithelial nests divided by scarce fibrovascular septa. The epithelial nests with peripheral palisading had uniform and oval nuclei with longitudinal grooves and swirling orientation. Significant atypia and mitotic activity were absent. Inside the nests there were foci of intraepithelial glandular metaplasia resembling glandular cystitis of the urinary bladder. MIB-1 index was 6%, and the distribution of MIB-1-positive nuclei was similar to that of immature metaplasia. A recurrence-free follow-up period of 16 months along with a low level of proliferation assessed by histology and immunohistochemistry suggests a benign nature of the lesion. A review of published transitional cell (urothelial) lesions of the female genital tract is added.