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Related Experiment Videos

Multicentric reticulohistiocytosis.

F B Luz1, Gaspar TAP, N Kalil-Gaspar

  • 1Sector of Dermatology, HUAP-UFF, Universidade Federal Fluminense, Niteroi, Brazil. flavioluz@dermatologista.net

Journal of the European Academy of Dermatology and Venereology : JEADV
|February 15, 2002
PubMed
Summary

Multicentric reticulohistiocytosis (MR) is a rare systemic disease affecting skin and joints. Early diagnosis and immunosuppressive treatment can improve patient outcomes.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Oncology

Background:

  • Multicentric reticulohistiocytosis (MR) is a rare systemic histiocytic disease.
  • Primarily affects skin and synovial joints.

Purpose of the Study:

  • To review current and novel aspects of MR.
  • Summarize key clinical, histopathological, and treatment data.

Main Methods:

  • Retrospective review of 96 worldwide case reports since 1977.
  • Literature synthesis of clinical presentations, diagnostic markers, and therapeutic strategies.

Main Results:

  • Common presentation includes facial/hand nodules and symmetric arthritis.
  • Characteristic 'coral beads' and vermicular lesions are noted.

Related Experiment Videos

  • Significant association with malignancy and specific immunohistochemical markers (vimentin, CD68, CD45).

    • Conclusions:

    • MR is a distinct histiocytic proliferative disorder.
    • Features a unique immunophenotypic profile and specific clinical/histopathological findings.
    • Immunosuppressive therapy may offer benefits despite a typically limiting prognosis.