The advantage of repair of mitral valve in acute endocarditis

Leonid Sternik1, Kenton J Zehr, Thomas A Orszulak

  • 1Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55902, USA.

Abstract

Insights

Mitral valve repair is superior to replacement for active endocarditis, showing better survival and fewer complications. Repair offers a significant advantage for patients with this condition.

Area of Science:

  • Cardiovascular Surgery
  • Infectious Diseases
  • Valvular Heart Disease

Background:

  • Mitral valve repair offers survival benefits for non-infectious mitral regurgitation.
  • The advantage of mitral valve repair over replacement in active endocarditis remains unclear.
  • This study compares morbidity, mortality, and event-free survival between repair and replacement for endocarditis.

Purpose of the Study:

  • To compare outcomes of mitral valve repair versus replacement in patients with active endocarditis.
  • To determine if mitral valve repair offers an advantage in terms of survival and complications.
  • To identify risk factors for mortality in patients undergoing mitral valve surgery for endocarditis.

Main Methods:

  • A retrospective study of 44 patients with acute native mitral valve endocarditis from 1986 to 1999.
  • Patients underwent either mitral valve replacement (28) or repair (16).
  • Repairs included simple and complex techniques, with detailed follow-up data.

Main Results:

  • No early or late deaths occurred in the repair group, versus 21% in-hospital and 21% late deaths in the replacement group (p <0.05).
  • Mitral valve replacement and need for associated procedures were independent risk factors for death.
  • Five patients needing replacement required reoperation for recurrent endocarditis; none in the repair group (p=0.065).

Conclusions:

  • Mitral valve repair is associated with better early and late mortality and event-free survival compared to replacement in acute endocarditis.
  • Valve repair should be prioritized for patients with active endocarditis whenever feasible.
  • Repair may reduce the need for reoperation in this patient population.

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...