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Published on: May 19, 2020
The advantage of repair of mitral valve in acute endocarditis
Leonid Sternik1, Kenton J Zehr, Thomas A Orszulak
1Division of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55902, USA.
Background And Aim Of The Study:
Mitral valve repair offers a survival benefit compared with valve replacement in surgery for non-infectious mitral regurgitation. It is unclear whether repair offers an advantage for patients undergoing mitral valve surgery for active endocarditis. Morbidity and mortality (early and late) and event-free survival were compared between the repair and replacement groups.
Methods:
Between September 1986 and July 1999, 44 patients with acute native mitral valve endocarditis underwent surgery; 28 patients had valve replacement, and 16 underwent repair. Nine patients had complex repairs including replacement of a portion of the leaflet with prosthetic patch, placement of artificial chordae, resection of a portion of both leaflets, and/or reconstruction of a commissure. The remainder had simple repairs.
Results:
Preoperative characteristics and indications for surgery between the two groups were similar. There were six in-hospital (21%) and six late cardiac deaths (21%) in the valve replacement group, but no early deaths or late cardiac deaths in the repair group (p <0.05). Independent risk factors for early and late death were need for associated procedures (p <0.03) and mitral valve replacement (p <0.05). Additional risk factors for late death were diabetes mellitus (p = 0.005) and hemodynamic instability as an indication for surgery (p = 0.047). Five patients undergoing valve replacement required reoperation due to recurrent endocarditis, compared with none in the repair group (p = 0.065). Mean follow up was 39+/-33 months in the repair group, and 57+/-51 months in the replacement group.
Conclusion:
Early and late mortality and event-free survival were better in patients undergoing mitral valve repair compared with replacement for acute endocarditis. Valve repair should be carried out whenever possible in this patient group.
Insights
Mitral valve repair is superior to replacement for active endocarditis, showing better survival and fewer complications. Repair offers a significant advantage for patients with this condition.
Area of Science:
- Cardiovascular Surgery
- Infectious Diseases
- Valvular Heart Disease
Background:
- Mitral valve repair offers survival benefits for non-infectious mitral regurgitation.
- The advantage of mitral valve repair over replacement in active endocarditis remains unclear.
- This study compares morbidity, mortality, and event-free survival between repair and replacement for endocarditis.
Purpose of the Study:
- To compare outcomes of mitral valve repair versus replacement in patients with active endocarditis.
- To determine if mitral valve repair offers an advantage in terms of survival and complications.
- To identify risk factors for mortality in patients undergoing mitral valve surgery for endocarditis.
Main Methods:
- A retrospective study of 44 patients with acute native mitral valve endocarditis from 1986 to 1999.
- Patients underwent either mitral valve replacement (28) or repair (16).
- Repairs included simple and complex techniques, with detailed follow-up data.
Main Results:
- No early or late deaths occurred in the repair group, versus 21% in-hospital and 21% late deaths in the replacement group (p <0.05).
- Mitral valve replacement and need for associated procedures were independent risk factors for death.
- Five patients needing replacement required reoperation for recurrent endocarditis; none in the repair group (p=0.065).
Conclusions:
- Mitral valve repair is associated with better early and late mortality and event-free survival compared to replacement in acute endocarditis.
- Valve repair should be prioritized for patients with active endocarditis whenever feasible.
- Repair may reduce the need for reoperation in this patient population.
Related Concept Videos
Mitral Regurgitation I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation III: Medical Management
Mitral Stenosis I: Introduction
Mitral Stenosis III: Medical Management
Myocarditis III: Medical Management

