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Malignant phyllodes tumor.

M Pandey1, A Mathew, J Kattoor

  • 1Division of Surgical Oncology, Regional Cancer Center, Medical College PO, Thiruvananthapuram, Kerala, India.

The Breast Journal
|February 15, 2002
PubMed
Summary
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Malignant phyllodes tumors in women require surgery with clear margins for best outcomes. Adjuvant radiotherapy may improve disease-free survival for these rare breast cancers.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Breast Cancer Research

Background:

  • Malignant phyllodes tumors (MPTs) are rare breast neoplasms with a potential for aggressive behavior.
  • Understanding prognostic factors is crucial for optimizing treatment strategies in MPT patients.

Purpose of the Study:

  • To evaluate the survival and prognostic factors associated with malignant phyllodes tumors.
  • To identify key clinical and treatment-related variables influencing patient outcomes.

Main Methods:

  • Retrospective analysis of 37 women diagnosed with MPT between 1982 and 1998.
  • Kaplan-Meier survival estimation and log-rank tests for factor comparison.
  • Cox-proportional hazard modeling to determine independent prognostic factors.

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Main Results:

  • The 5-year overall survival was 74.2% and disease-free survival was 59.6%.
  • Surgical margin status was the sole independent prognostic factor (p=0.003).
  • Factors associated with decreased hazard included adjuvant radiotherapy, being married, and age over 35.

Conclusions:

  • Adequate surgical excision with clear margins is paramount for managing malignant phyllodes tumors.
  • Adjuvant radiotherapy may enhance disease-free survival, warranting further investigation.
  • Tumor size >5 cm is linked to increased hazard, emphasizing the need for early detection and intervention.