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Helicobacter pylori and tonsillectomy.

L J Skinner1, D C Winter, A J Curran

  • 1Department of Otolaryngology, Royal Victoria Eye and Ear Hospital, Adelaide Road, Dublin 2, Ireland. skinnerljs@yahoo.com

Clinical Otolaryngology and Allied Sciences
|February 15, 2002
PubMed
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Helicobacter pylori does not colonize tonsils, but seropositive individuals show increased inducible nitric oxide synthase (iNOS) in tonsillar macrophages. This suggests H. pylori primes tonsils, indicating a local and systemic inflammatory response.

Area of Science:

  • Immunology
  • Microbiology
  • Otorhinolaryngology

Background:

  • Tonsillar tissue, part of mucosa-associated lymphoid tissue (MALT), protects mucosal surfaces.
  • Helicobacter pylori, linked to ulcers and gastritis, forms MALT in the stomach and is cytotoxic.
  • The potential role of tonsils in H. pylori processing or colonization is unexplored.

Purpose of the Study:

  • To investigate if Helicobacter pylori colonizes palatine tonsils.
  • To determine H. pylori's role in tonsillitis pathogenesis.
  • To assess the association between H. pylori and inducible nitric oxide synthase (iNOS) expression in tonsillar macrophages.

Main Methods:

  • Prospective study of 50 tonsillectomy patients.
  • Serological testing for H. pylori antibodies.

Related Experiment Videos

  • Tonsillar specimens analyzed for urease activity (CLO test), H. pylori presence (immunocytochemistry), and iNOS expression.

    • Main Results:

    • 28% of patients were seropositive for H. pylori; none had tonsillar evidence of the pathogen.
    • No H. pylori colonization was detected in tonsillar tissue.
    • Sero-positive patients showed significantly increased iNOS expression in tonsillar macrophages (13.3 vs. 9.9, P=0.01).

    Conclusions:

    • Helicobacter pylori does not colonize the palatine tonsils.
    • H. pylori infection appears to induce iNOS expression in tonsillar macrophages.
    • Increased iNOS suggests H. pylori primes tonsils, contributing to a local and systemic inflammatory response.