Related Experiment Videos
Myxoid adrenal cortical adenoma
1Department of Pathology, Oita Medical University, Oita, Japan. hondak@oita-med.ac.jp
Pathology International
|February 15, 2002
Summary
This study describes a rare myxoid adrenal cortical adenoma in a Japanese man. The tumor showed distinct histological features, including a gelatinous myxoid stroma, with no signs of malignancy.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Myxoid adrenal cortical adenoma is an exceptionally rare adrenal tumor, with limited documented cases.
- Adrenal masses discovered during routine examinations necessitate thorough histopathological evaluation.
Observation:
- A 56-year-old Japanese man presented with a right adrenal mass identified incidentally.
- Gross examination revealed a well-circumscribed mass with distinct canary yellow multinodular and brown gelatinous regions.
- Histology showed conventional adenoma-like areas alongside a myxoid stroma rich in acidic mucopolysaccharides.
Findings:
- Immunohistochemistry showed focal vimentin positivity and a low MIB-1 labeling index (<1%), indicating low proliferative activity.
- Flow cytometry confirmed diploid cells, further supporting benignancy.
- Ultrastructural analysis revealed lipid-rich cells in multinodular areas and mitochondria-rich cells in the myxoid regions.
Implications:
- The findings are consistent with an adenoma, lacking any indicators of malignancy.
- The origin and mechanism of acidic mucopolysaccharide production in this rare tumor require further investigation.
- This case contributes to the understanding of rare adrenal cortical neoplasms and their unique histological presentations.