Related Experiment Video
Updated: Jul 28, 2026
09:03
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Crown-rump lengths in missed miscarriages and trisomy 21
N A Ginsberg1, C Strom, Y Verlinsky
1Department of Obstetrics and Gynecology, Division of Medical Genetics, Illinois Masonic Hospital and Medical Center, Chicago, USA. nag709@nwu.edu
Summary
In missed miscarriages among women over 35, a fetal crown-rump length of 22 mm or greater suggests trisomy 21 is a likely cause. This finding aids in early diagnosis of chromosomal abnormalities.
Area of Science:
- Reproductive Medicine
- Prenatal Diagnosis
- Genetics
Background:
- Missed miscarriage is a pregnancy complication.
- Trisomy 21 is a common chromosomal abnormality.
- Early identification of miscarriage etiology is crucial.
Purpose of the Study:
- To compare fetal crown-rump lengths with karyotypes in missed miscarriages.
- To establish a correlation between crown-rump length and trisomy 21.
Main Methods:
- 129 missed miscarriages in women aged >= 35 were analyzed.
- Chorionic villus sampling was performed for karyotyping.
- Crown-rump length was measured and correlated with karyotype results.
Main Results:
- Trisomy 21 was identified in 21 of 129 cases.
- Fetuses with trisomy 21 had significantly larger crown-rump lengths (P < 0.0001) at 10-12 weeks.
- A crown-rump length of >= 22 mm predicted trisomy 21 with 86% sensitivity and 89% specificity.
Conclusions:
- In women >= 35 with missed miscarriage at >= 10 weeks, a fetal crown-rump length of >= 22 mm indicates a high probability of trisomy 21.
- This measurement can aid in predicting the cause of missed miscarriage.
- Crown-rump length serves as a potential early indicator for trisomy 21 in missed miscarriages.
More Related Videos
11:54Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
09:30Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
Published on: August 17, 2022
Related Concept Videos
01:49Meiosis I
Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
01:17Karyotyping
Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
01:29Nondisjunction
During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.
02:57Meiosis vs. Mitosis
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
01:21Nondisjunction
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...