Ca(2+) oscillations and sperm factors at fertilization in mammals

At fertilization in mammals, the spermatozoon triggers a series of Ca(2+) oscillations that are essential for activating the oocyte. The reason why the spermatozoon triggers Ca(2+) oscillations, as opposed to a single Ca(2+) increase, is unknown. However, there is evidence that more than one Ca(2+) increase is required for efficient rates of pronuclear formation. In addition, the pattern of Ca(2+) oscillations may affect later development. It is not known how the spermatozoon triggers Ca(2+) release in the oocyte, but it may act by introducing a cytosolic factor after gamete membrane fusion has taken place. This factor is characterized by its ability to cause Ca(2+) oscillations and is referred to as an oscillogen. The protein components that make up the sperm oscillogen remain unclear.