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Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors
Amit S Kalgutkar1, Scott W Rowlinson, Brenda C Crews
1A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. amit_kalgutkar@groton.pfizer.com
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.