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Cytotoxic and antibacterial activity of 2-oxopurine derivatives
Geir Andresen1, Lise-Lotte Gundersen, Jon Nissen-Meyer
1Department of Chemistry, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
Initial screening of the cytotoxic and antibacterial properties of 6-substituted 2-oxopurines and dihydro-2-oxopurines revealed that several compounds exhibited cytotoxicity against K-562 cells in the same range as the well known antileukemic drug 6-mercaptopurine. Most compounds were also tested for inhibitory effect on a Gram-positive bacterium, Lactobacillus casei, as well as the mycobacterium Mycobacterium tuberculosis. Generally the 2-oxopurines exhibited low antibacterial effect.