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Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
Published on: June 23, 2011
Absorption studies on aminoglycoside binding to the packaging region of human immunodeficiency virus type-1
Julie M Sullivan1, Jerry Goodisman, James C Dabrowiak
1Department of Chemistry, CST 1-014, Syracuse University, Syracuse, NY 13244, USA.
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
The binding of paromomycin, neomycin B, and three analogues of neomycin to a 176-mer RNA from the packaging region of HIV-1 (LAI) has been studied using UV absorption spectroscopy at wavelengths between 200 and 300 nm. From plots of absorption as a function of drug concentration, values of binding constants for these drugs on RNA were determined.
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