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Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase
Rebekah Beevers1, Maria G Carr, Philip S Jones
1Department of Chemistry, Roche Discovery Welwyn, 40 Broadwater Road, Welwyn Garden City, AL7 3AY, Hertfordshire, UK.
Bioorganic & Medicinal Chemistry Letters
|February 15, 2002
Abstract:
A versatile route for the synthesis of homochiral alpha-ketoamide analogues of amino acids is described. Incorporation of this functionality into peptide sequences using either solution or solid-phase chemistry resulted in potent inhibitors of the Hepatitis C Virus NS3 proteinase.