Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain atrophy in clinically early relapsing-remitting multiple sclerosis.

D T Chard1, C M Griffin, G J M Parker

  • 1NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, UK.

Brain : a Journal of Neurology
|February 15, 2002
PubMed
Summary

Brain atrophy, impacting grey and white matter, is evident early in multiple sclerosis (MS). Quantitative MRI reveals significant tissue loss, suggesting disease mechanisms independent of visible lesions in early stages.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B.

The Journal of infectious diseases·2025
Same author

Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial.

Journal of viral hepatitis·2025
Same author

Editorial: Ultralow HBsAg Levels and the Prediction of Cure in Chronic Hepatitis B.

Alimentary pharmacology & therapeutics·2025
Same author

New insights into the effects of ethylene on ABA catabolism, sweetening and dormancy in stored potato tubers.

Postharvest biology and technology·2021
Same author

Direct Measurement of Single-Molecule Ligand-Receptor Interactions.

The journal of physical chemistry. B·2020
Same author

Prevalence of baseline HCV NS5A resistance associated substitutions in genotype 1a, 1b and 3 infection in Australia.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2019

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Brain atrophy is a key MRI marker for multiple sclerosis (MS) progression.
  • Understanding early brain atrophy and its relation to lesions is crucial for MS management.
  • Current documentation of early MS brain atrophy mechanisms is limited.

Purpose of the Study:

  • To investigate whole brain, grey matter, and white matter atrophy in early relapsing-remitting MS.
  • To correlate brain atrophy measures with lesion load using quantitative MRI.
  • To elucidate the mechanisms of brain atrophy in early MS.

Main Methods:

  • Quantitative MRI (3D FSPGR, T1-weighted, T2-weighted) was used.
  • Automated segmentation (SPM99) identified grey matter, white matter, and CSF volumes.

Related Experiment Videos

  • Semi-automatic lesion segmentation quantified lesion volumes.

    • Main Results:

    • Significantly reduced brain parenchymal fraction (BPF), grey matter fraction (GMF), and white matter fraction (WMF) in MS patients compared to controls (P < 0.001).
    • T2 hyper-intense and T1 hypo-intense lesion volumes inversely correlated with BPF and GMF (P < 0.006).
    • No significant correlation was found between lesion volumes and WMF, or with T1 post-gadolinium-enhancing lesions.

    Conclusions:

    • Significant brain atrophy affecting both grey and white matter occurs early in MS.
    • White matter atrophy may involve mechanisms independent of overt lesion formation in early MS.
    • Quantitative MRI is valuable for assessing early brain atrophy in MS.