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Related Concept Videos

Sex-linked Disorders01:43

Sex-linked Disorders

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Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
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Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

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Huntington Disease l: Introduction

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Related Experiment Video

Updated: Jul 23, 2026

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome
09:39

Generation of Induced Pluripotent Stem Cells from Turner Syndrome (45XO) Fetal Cells for Downstream Modelling of Neurological Deficits Associated with the Syndrome

Published on: December 4, 2021

Turner's syndrome in adulthood.

M Elsheikh1, D B Dunger, G S Conway

  • 1Department of Endocrinology, Radcliffe Infirmary, Oxford, OX2 6HE, United Kingdom.

Endocrine Reviews
|February 15, 2002
PubMed
Summary

Turner's syndrome, a common female chromosomal abnormality, causes short stature and ovarian failure. Multidisciplinary care is vital for adults with Turner's syndrome to improve health and longevity.

Area of Science:

  • Genetics
  • Endocrinology
  • Cardiology

Background:

  • Turner's syndrome is the most frequent chromosomal abnormality in females.
  • It results from an absent or abnormal X chromosome, leading to short stature and ovarian failure.
  • Adults with Turner's syndrome face increased risks of osteoporosis, hypothyroidism, renal, and gastrointestinal diseases.

Purpose of the Study:

  • To highlight the increased morbidity and reduced life expectancy in adults with Turner's syndrome.
  • To emphasize the link between Turner's syndrome and cardiovascular issues like aortic dissection and ischemic heart disease.
  • To advocate for improved healthcare access and management for women with Turner's syndrome.

Main Methods:

  • Review of existing literature on Turner's syndrome comorbidities.

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  • Analysis of recent evidence regarding life expectancy and causes of mortality.
  • Assessment of the impact of healthcare access on quality of life.

    • Main Results:

    • Turner's syndrome is associated with significant long-term health issues beyond initial diagnosis.
    • Cardiovascular complications, including aortic dissection and ischemic heart disease, contribute to reduced life expectancy.
    • Lack of focused healthcare has historically diminished the quality of life for affected women.

    Conclusions:

    • Adults with Turner's syndrome require comprehensive, multidisciplinary care.
    • Proactive management can mitigate risks, improve life expectancy, and enhance quality of life.
    • Specialized follow-up is crucial for addressing the complex health needs of women with Turner's syndrome.