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Polychlorinated biphenyls and hexachlorobenzene in full-term neonates. Reference values updated
1Zentrum für Kinderheilkunde, Heinrich-Heine-Universität, Düsseldorf, Deutschland. GMLackmann@t-online.de
Biology of the Neonate
|February 15, 2002
Summary
Prenatal exposure to polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) has significantly decreased. Reference values for PCBs and HCB in neonates show a continued decline, indicating reduced environmental contamination.
Area of Science:
- Environmental Health
- Toxicology
- Pediatric Health
Background:
- Persistent organic pollutants like PCBs and HCB pose risks to infant health.
- Monitoring prenatal exposure is crucial for assessing population health trends.
Purpose of the Study:
- To establish current reference values for polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) in full-term neonates.
- To assess trends in prenatal exposure to these contaminants.
Main Methods:
- Cord blood samples from 200 healthy neonates were analyzed for six PCB congeners and HCB using gas chromatography.
- Reference values were determined using the 95th percentile by rank, with statistical analysis for group differences.
Main Results:
- Concentrations of lower-chlorinated PCBs were mostly below detection limits.
- Reference values (95th percentile) were established: PCB 138 (0.5 µg/l), PCB 153 (0.5 µg/l), PCB 180 (0.4 µg/l), and HCB (0.5 µg/l).
Conclusions:
- A significant decline in prenatal exposure to PCBs (75%) and HCB (90%) was observed compared to 1994-1995.
- These findings suggest reduced environmental contamination and successful public health interventions.