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A low serum sICAM-1 level may assist in the exclusion of neonatal infection

David Edgar1, Vanessa Gabriel, Adam Craig

  • 1Regional Immunology Service, Royal Hospitals Trust, Belfast, UK. david-edgar@bll.n-i.nhs.uk

Biology of the Neonate
|February 15, 2002
PubMed

Insights

Serum soluble intercellular adhesion molecule-1 (sICAM-1) levels are significantly elevated in infected infants. Low sICAM-1 levels may help exclude infection in critically ill infants.

Area of Science:

  • Pediatric Intensive Care
  • Biomarker Discovery
  • Infectious Disease Diagnostics

Background:

  • Infections in critically ill infants pose diagnostic challenges.
  • Intercellular Adhesion Molecules (ICAMs) play a role in inflammatory and immune responses.
  • Soluble ICAM-1 (sICAM-1) is a potential biomarker for inflammatory conditions.

Purpose of the Study:

  • To investigate serum sICAM-1 levels in infants in intensive care.
  • To determine if sICAM-1 can differentiate infected from non-infected infants.
  • To assess the utility of sICAM-1 as a diagnostic marker for infection in this population.

Main Methods:

  • Serum samples from 46 infants in intensive care were analyzed.
  • Soluble intercellular adhesion molecule-1 (sICAM-1) levels were measured using ELISA.
  • Retrospective chart review identified infection status (proven, probable, or non-infected).

Main Results:

  • Serum sICAM-1 levels were significantly higher in infants with proven or probable infections compared to non-infected infants (p < 0.001).
  • sICAM-1 levels in serum were consistent with previously reported plasma levels.
  • The test demonstrated robustness in differentiating infection status.

Conclusions:

  • Serum sICAM-1 measurement is a simple and effective test for distinguishing infected from non-infected infants.
  • Elevated serum sICAM-1 levels indicate infection in critically ill infants.
  • Low serum sICAM-1 levels may be valuable in ruling out infection.

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