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Related Experiment Videos

Substrate utilization by the inactive leg during one-leg or arm exercise.

G Ahlborg, L Hagenfeldt, J Wahren

    Journal of Applied Physiology
    |November 1, 1975
    PubMed
    Summary

    During exercise, the nonexercising leg increases oxygen and glucose uptake, shifting to carbohydrate utilization. Muscles and adipose tissue aid in lactate removal, highlighting metabolic adaptations during physical exertion.

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    Area of Science:

    • Exercise Physiology
    • Human Metabolism
    • Sports Science

    Background:

    • Understanding substrate utilization in nonexercising limbs during unilateral exercise is crucial for comprehending whole-body metabolic responses.
    • Previous research has primarily focused on exercising muscle metabolism, with less attention paid to the contralateral limb.

    Purpose of the Study:

    • To investigate substrate utilization and metabolic changes in the nonexercising leg during one-leg and arm exercise in healthy individuals.
    • To determine the role of the nonexercising leg in substrate uptake and lactate metabolism during different exercise modalities.

    Main Methods:

    • Healthy subjects performed either one-leg exercise (105 W, 40 min) or arm exercise (65 W, 20 min).
    • Measurements included leg blood flow, arterial-femoral venous (A-FV) differences for oxygen and glucose, lactate exchange, and electromyography (EMG) activity.

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  • Substrate uptake was estimated based on blood flow and A-FV differences.

    • Main Results:

    • During one-leg exercise, nonexercising leg oxygen uptake increased fivefold due to increased blood flow and oxygen A-FV difference, with elevated EMG.
    • Glucose uptake in the nonexercising leg increased fourfold, despite stable or falling insulin levels.
    • Arm exercise led to a 20-70% rise in leg blood flow and 25-45% increase in oxygen uptake with minimal leg EMG, accompanied by significant lactate uptake.

    Conclusions:

    • The nonexercising leg undergoes significant metabolic alterations during physical exertion, including increased blood flow and oxygen uptake, partly due to motor activation.
    • Substrate utilization shifts from free fatty acids (FFA) to carbohydrates in the nonexercising leg.
    • Nonexercising muscle and adipose tissue contribute to lactate removal during exercise.