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Malignant fibrous histiocytoma associated with a meningothelial meningioma

D Schiffer1, A Ferraiolo, V Fiano

  • 1Department of Neuroscience, University of Turin, Italy. davide.schiffer@unito.it

Clinical Neuropathology
|February 16, 2002
PubMed

Insights

This study reports a rare case of a meningioma with malignant fibrous histiocytoma, a dual-component brain tumor. Surgical removal and radiation therapy led to a positive outcome for the patient.

Area of Science:

  • Neuro-oncology
  • Surgical Pathology

Background:

  • Meningiomas are tumors arising from the meninges, the membranes surrounding the brain and spinal cord.
  • Malignant fibrous histiocytoma (MFH) is a rare soft tissue sarcoma.
  • Dual-component tumors involving meningioma and MFH are exceptionally uncommon.

Observation:

  • A 72-year-old woman presented with a left parietal tumor diagnosed as a meningothelial meningioma with an associated malignant fibrous histiocytoma.
  • Histological examination revealed a meningioma component with whorl formation and a pleomorphic MFH component exhibiting storiform architecture, giant cells, necrosis, and mitotic activity.
  • The MFH component appeared to originate from the meningioma septa, indicating a potential transition or co-occurrence.

Findings:

  • The study details the distinct histological features of both the meningioma and MFH components.
  • The presence of nuclear inclusions and absence of mitotic activity in the meningioma contrasted with the high mitotic rate and atypical features of the MFH.
  • Inflammatory infiltrates were also noted at the interface between the two tumor types.

Implications:

  • This case highlights the importance of thorough histological examination for identifying rare dual-component tumors.
  • Understanding the potential origin and interaction between meningioma and MFH is crucial for accurate diagnosis and treatment planning.
  • The successful management with surgery and radiation suggests a viable therapeutic approach for such rare entities.

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