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Microwave induced synthesis and antibacterial activity of cephalosporin derivatives using solid support
M Kidwai1, P Sapra, K R Bhushan
1Department of Chemistry, University of Delhi, Delhi, 110007, India. mkidwai@mantraonline.com
Bioorganic Chemistry
|February 16, 2002
Abstract:
Reaction of 7-amino-3-[5'-methyl-1',3',4'-thiadiazol-2'-ylthiomethyl]cephalo-sporanic acid with heterocyclic amines using basic alumina under microwave irradiation (MWI) afforded new cephalosporin analogs in shorter reaction time with improved yield as compared to conventional heating. All the synthesised compounds were tested for their in vitro antibacterial activity, using cefotaxime and cephalothin as reference drugs. All compounds showed significant in vitro antibacterial activity against E. herbicola, P. vulgaries, and Z. mobilis.