The effect of sensory denervation on rabbits' knee joints. A light and electron microscopic study

Unilateral sensory denervation of the hind limb in a group of rabbits caused progressive atrophy of cells in all structures of the knee joint, whether or not the joint was protected by a plaster cast. Immobilization without denervation caused proliferative changes, first in the synovium and then in the articular cartilage. The initial changes in the articular cartilage following sensory denervation occurred in the middle layers, suggesting that nutritional deficiency was involved. In contrast, the first changes in the cartilage of intact immobilized limbs occurred in the superficial layers and were most likely of mechanical origin.