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Updated: Oct 2, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
An improved synthesis of a trifurcated newkome-type monomer and orthogonally protected two-generation dendrons
Claudia M Cardona1, Robert E Gawley
1Department of Chemistry and NIEHS Marine and Freshwater Biomedical Sciences Center, University of Miami, P.O. Box 249118, Coral Gables, Florida 33124-0431, USA.
Abstract:
The one-step synthesis of amino-polyether tri-tert-butyl ester monomer 2, by condensation of TRIS with tert-butyl acrylate, is reported. The nitrogen of the monomer can be protected with a Cbz group; subsequent removal of the tert-butyl esters with formic acid affords a triacid that is coupled to three monomers to afford an orthogonally protected two-generation, trifurcated polyether-polyamide dendron. The Cbz protecting group may be removed from the second-generation dendron without disturbing the tert-butyl esters of the periphery.
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