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Related Experiment Videos

Gynecomastia with sulpiride.

Y Kaneda1, A Fujii

  • 1Department of Neuropsychiatry, The University of Tokushima School of Medicine, Tokushima, Japan. kaneday@clin.med.tokushima-u.ac.jp

Journal of Clinical Pharmacy and Therapeutics
|February 16, 2002
PubMed
Summary

Sulpiride, a neuroleptic, may cause unilateral gynecomastia by increasing prolactin (PRL) and altering the testosterone (T)/estradiol (E2) ratio. Discontinuing the drug reduced breast enlargement in a case study.

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Area of Science:

  • Endocrinology
  • Neuropharmacology

Background:

  • Neuroleptic agents are linked to gynecomastia, but causal evidence is limited.
  • Generalized anxiety disorder is a common condition treated with various medications.

Observation:

  • A 38-year-old man developed unilateral gynecomastia during sulpiride treatment.
  • No endocrine abnormalities were noted besides elevated prolactin (PRL) and a decreased testosterone (T)/estradiol (E2) ratio.

Findings:

  • Sulpiride treatment correlated with increased PRL and decreased T/E2 ratio.
  • Gynecomastia symptoms resolved after sulpiride discontinuation.

Implications:

  • Sulpiride may induce gynecomastia through direct hypothalamic-pituitary inhibition or hyperprolactinemia.
  • This case highlights a potential adverse effect of sulpiride on endocrine function.

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