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Functional activity within brain tumors: a magnetic source imaging study.

H Schiffbauer1, P Ferrari, H A Rowley

  • 1Oulu Clinic for Neurosurgery, University of Oulu, Oulu, Finland.

Neurosurgery
|February 16, 2002
PubMed
Summary
This summary is machine-generated.

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Low-grade gliomas showed functional cortical activity more often within tumor tissue than high-grade gliomas. Preoperative functional imaging is crucial for safe tumor resection.

Area of Science:

  • Neurosurgery
  • Neuroscience
  • Medical Imaging

Background:

  • Intra-axial brain tumors can infiltrate or border functional cortical areas.
  • Accurate localization of functional cortex is vital for surgical planning to minimize neurological deficits.

Purpose of the Study:

  • To compare the prevalence of functional cortical activity within radiologically defined abnormal tissue in low-grade versus high-grade gliomas.
  • To assess the necessity of preoperative functional imaging for optimizing tumor resection.

Main Methods:

  • Retrospective analysis of 106 patients with intra-axial cerebral lesions near eloquent cortex.
  • Preoperative magnetic source imaging (MSI) using a dual 37-channel biomagnetometer.
  • Analysis of evoked magnetic fields from somatosensory and auditory stimuli to identify neuronal sources.

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Main Results:

  • Functional activity was found within the tumor lesion in 18% of Grade 2, 17% of Grade 3, and 8% of Grade 4 gliomas.
  • 24.5% of patients were at risk for neurological deficits due to functional tissue proximity.
  • High-grade lesions were more frequently associated with functional cortex at margins or in peritumoral edema.

Conclusions:

  • Intra-axial brain tumors, irrespective of grade, can involve or border functional cortex.
  • Functionally viable cortex involvement was greater in low-grade gliomas compared to high-grade lesions.
  • Preoperative functional imaging and intraoperative mapping are essential for safe and maximal tumor resection.