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The hemangioblast: a common progenitor of hematopoietic and endothelial cells

Kyunghee Choi1

  • 1School of Medicine, Department of Pathology and Immunology, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110, USA. kchoi@immunology.wustl.edu

Journal of Hematotherapy & Stem Cell Research
|February 16, 2002
PubMed

In the developing embryo, the initial hematopoietic and vascular structure can be identified as the blood islands of the yolk sac. Blood islands are formed from mesodermal aggregates that have migrated from the primitive streak. The outer cells differentiate into endothelial cells and the inner to primitive blood. The close developmental association between hematopoietic and endothelial cell lineages has led to a hypothesis that they share a common progenitor, the hemangioblast. This review will examine emerging studies supporting the existence of such cells in order to further understand how the hematopoietic and vascular systems are established during mouse development.

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