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Diffusion-weighted MR imaging in normal human brains in various age groups.

Johanna Helenius1, Lauri Soinne, Jussi Perkiö

  • 1Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland.

AJNR. American Journal of Neuroradiology
|February 16, 2002
PubMed
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This study establishes reference apparent diffusion coefficient (ADC) values for the healthy human brain. Absolute ADC values in most brain regions do not significantly change with age, sex, or hemisphere.

Area of Science:

  • Neuroimaging
  • Diffusion Tensor Imaging (DTI)
  • Human Brain Anatomy

Background:

  • Limited data exists on absolute apparent diffusion coefficient (ADC) values in the healthy human brain.
  • The impact of aging on brain diffusion characteristics requires further investigation.

Purpose of the Study:

  • To determine if average ADC (ADC(av)) values vary with age, sex, or hemisphere in the brain.
  • To establish normative ADC(av) reference values for future research and clinical applications.

Main Methods:

  • MR imaging, including diffusion-weighted imaging, was performed on 80 healthy subjects (40 men, 40 women) across four age groups.
  • Bilateral ADC(av) values were measured in 36 regions of interest throughout the brain using two b values (0 and 1000 s/mm(2)) at 1.5 T.
  • Statistical analysis was conducted to assess differences based on age, sex, and hemisphere.

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Main Results:

  • Apparent diffusion coefficient (ADC(av)) values were highest in cortical gray matter, intermediate in deep gray matter, and lowest in white matter.
  • No significant changes in ADC(av) values were observed with aging, except for an increase in the lateral ventricles.
  • No significant differences in ADC(av) values were found between sexes or between the left and right hemispheres.

Conclusions:

  • The established ADC(av) values provide representative reference data for the healthy human brain.
  • These normative values are valuable for future neuroimaging studies and clinical diagnostic settings.
  • The findings indicate that age, sex, and hemisphere do not significantly influence ADC(av) in most brain regions.