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Interactive InterPro-based comparisons of proteins in whole genomes
A Kanapin1, R Apweiler, M Biswas
1EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. alex@ebi.ac.uk
Bioinformatics (Oxford, England)
|February 16, 2002
Summary
The Proteome Analysis Database offers integrated comparative analysis of predicted protein sequences from complete bacterial, archaeal, and eukaryotic genomes. An accompanying program enables interactive InterPro proteome comparisons across diverse species.
Area of Science:
- Bioinformatics
- Proteomics
- Genomics
Background:
- The SWISS-PROT group at the European Bioinformatics Institute (EBI) developed the Proteome Analysis Database.
- This database integrates existing resources for comprehensive analysis of predicted protein-coding sequences.
- It covers complete genomes of bacteria, archaea, and eukaryotes.
Purpose of the Study:
- To provide a tool for comparative proteome analysis.
- To facilitate interactive comparisons of proteomes using InterPro data.
- To enable researchers to compare any proteome within the database against others.
Main Methods:
- Utilizing existing bioinformatics resources.
- Developing a comprehensive database of predicted protein-coding sequences from complete genomes.
- Creating an interactive program for InterPro proteome comparisons.
Main Results:
- A comprehensive and integrated database of proteomic information.
- A functional program for interactive comparative proteome analysis.
- The ability to compare any proteome against multiple others within the database.
Conclusions:
- The Proteome Analysis Database provides a valuable resource for comparative genomics and proteomics.
- The interactive comparison tool enhances the utility of the database for researchers.
- Facilitates deeper insights into protein function and evolution across different domains of life.