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Related Experiment Videos

Engineered antibodies take center stage.

J S Huston1, A J George

  • 1Lexigen Pharmaceuticals Corp, 125 Hartwell Avenue, Lexington, MA 02421-3125, USA. jhuston@lexigenpharm.com

Human Antibodies
|February 16, 2002
PubMed
Summary
This summary is machine-generated.

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Antibody engineering advances, including phage display, are crucial for understanding gene function and developing targeted immunotherapies. This field is rapidly expanding, with significant growth in clinical applications and therapeutic agents.

Area of Science:

  • * Molecular Biology and Immunology: Focus on antibody engineering as a critical technology.
  • * Genomics and Proteomics: Application of engineered antibodies in understanding gene function and protein expression.

Background:

  • * The post-genomic era highlights the importance of antibody engineering for linking genomic sequence to biological function and pathology.
  • * Progress in phage display antibody libraries enables novel gene function discovery and measurement of abnormal protein expression.

Purpose of the Study:

  • * To review the state of antibody engineering and its advancements.
  • * To discuss the role of antibody engineering in proteomics, molecular medicine, and targeted immunotherapies.
  • * To highlight progress and future directions presented at the 11th Annual International Conference on Antibody Engineering.

Main Methods:

  • * Review of advancements in antibody engineering, including phage display libraries.

Related Experiment Videos

  • * Analysis of clinical trials and regulatory approvals of engineered antibodies.
  • * Discussion of research presented at the 11th Annual International Conference on Antibody Engineering.

    • Main Results:

    • * Engineered antibodies are increasingly used in proteomics for gene function and pathology studies.
    • * Significant clinical success has been achieved in developing targeted immunotherapies for cancer and other diseases.
    • * Monoclonal antibody therapeutics show dramatic clinical acceptance, with substantial market growth.

    Conclusions:

    • * Antibody engineering is a rapidly advancing field with profound implications for medicine and biology.
    • * Continued research and investment are expected to accelerate the development of life-saving immunotherapeutic agents.
    • * The field is characterized by a strong drive towards practical applications and clinical translation.