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Bupropion-induced acute dystonia
Mark B Detweiler1, Gary J Harpold
1Department of Psychiatric Medicine (116A7), Salem Veterans Affairs Medical Center, University of Virginia, Salem-Roanoke, 1970 Roanoke Blvd., Salem, VA 24153-6478, USA. Detweiler.Mark_B@Salem.VA.Gov
The Annals of Pharmacotherapy
|February 19, 2002
Summary
Bupropion sustained-release (SR) may cause acute dystonia, including neck stiffness and jaw pain, in some patients. This case highlights a potential dose-response relationship for bupropion-induced dystonic reactions.
Area of Science:
- Neuroscience
- Pharmacology
- Clinical Medicine
Background:
- Acute dystonia is a movement disorder characterized by involuntary muscle contractions.
- Bupropion is an antidepressant medication that affects neurotransmitter systems.
- Temporomandibular joint (TMJ) disorders can manifest with jaw pain and dysfunction.
Observation:
- A patient developed neck stiffness, trismus, and TMJ subluxation after increasing bupropion SR dosage.
- Symptoms resolved upon dose reduction and recurred with dose escalation, suggesting a dose-response effect.
- Buspirone augmentation did not appear to cause dystonia when bupropion was discontinued.
Findings:
- The case suggests a potential link between bupropion SR and acute focal dystonia.
- A dose-response relationship was observed, with symptoms appearing at higher bupropion SR doses.
- This represents a rare adverse reaction, as bupropion-induced dystonia has not been previously reported.
Implications:
- Clinicians should be aware of the potential for bupropion-induced dystonia, particularly at higher doses.
- Monitoring for neck and jaw movement abnormalities is crucial in patients taking bupropion SR.
- Further research may be needed to elucidate the mechanisms of bupropion-induced dystonia.