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Intestinal satiety in rats.

D S Liebling, J D Eisner, J Gibbs

    Journal of Comparative and Physiological Psychology
    |October 1, 1975
    PubMed
    Summary
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    Infusing liquid food into the duodenum triggers intestinal satiety, a reflex response. This satiety mechanism, potentially mediated by cholecystokinin (CCK), is not aversive and plays a key role in appetite regulation.

    Area of Science:

    • Gastroenterology
    • Neuroscience
    • Physiology

    Background:

    • Satiety, the feeling of fullness, is crucial for regulating food intake.
    • The role of intestinal factors in triggering satiety signals is an area of ongoing research.
    • Previous studies suggest the intestine plays a role in satiety, but the precise mechanisms are not fully understood.

    Purpose of the Study:

    • To investigate whether direct infusion of liquid food into the duodenum can elicit satiety.
    • To characterize the nature of satiety induced by duodenal infusion.
    • To explore the potential involvement of the hormone cholecystokinin (CCK) in this process.

    Main Methods:

    • Rats were subjected to sham feeding (simulated eating without ingestion).
    • Liquid food was infused directly into the duodenum.

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  • Behavioral responses associated with satiety were observed and analyzed.
  • The potential for duodenal infusions to act as a conditioned taste aversion stimulus was tested.

    • Main Results:

    • Duodenal infusion of liquid food significantly inhibited sham feeding.
    • The observed inhibition was characterized by a complete behavioral sequence indicative of satiety.
    • Duodenal infusions that induced satiety were not aversive and did not lead to conditioned taste aversion.
    • The hormone cholecystokinin (CCK) was found to mimic the effects of duodenal infusion, inhibiting sham feeding and eliciting satiety behaviors.

    Conclusions:

    • Satiety can be elicited by direct stimulation of the duodenum, termed "intestinal satiety."
    • Intestinal satiety appears to be a reflex mediated by receptors in the intestinal wall.
    • Cholecystokinin (CCK) is a likely mediator of intestinal satiety in rats, although further proof is needed.