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Radio-and chemotoxicity in mice during hypothermia
L Lundgren-Eriksson1, A Palm, W Ryd
1Department of Radiation Sciences, Oncology, Umeå University, Sweden. lotta.lundgren.eriksson@onkologi.umu
Anticancer Research
|February 19, 2002
Summary
Induced hypothermia significantly reduces toxicity from radiation, doxorubicin, and cisplatin in mice. This protective effect, driven by lower temperatures, also enhanced anti-cancer activity, particularly with cisplatin.
Area of Science:
- Oncology
- Radiology
- Pharmacology
Background:
- Investigating the impact of chlorpromazine-induced hypothermia on C57B1-mice survival.
- Assessing effects in mice with and without tumor inoculation.
Purpose of the Study:
- To determine if hypothermia influences survival rates after radiation and chemotherapy.
- To evaluate the role of temperature versus chlorpromazine in observed effects.
- To assess the impact on anti-tumor activity.
Main Methods:
- Mice exposed to whole-body irradiation (8 Gy), doxorubicin (15 or 17.5 mg/kg), or cisplatin (20 mg/kg).
- Control mice maintained normal temperature (38°C); experimental mice developed hypothermia (28°C or 36°C).
- Survival and tumor progression monitored.
Main Results:
- Hypothermia (28°C) protected against radiation and doxorubicin toxicity, with males showing greater protection.
- Hypothermia also protected against cisplatin toxicity and enhanced anti-tumor effects in both sexes.
- Effects were temperature-dependent, not attributable to chlorpromazine itself.
Conclusions:
- Moderate hypothermia (28°C) significantly reduces toxicity from radiation, doxorubicin, and cisplatin in mice.
- Males experienced greater protection from hypothermia-induced toxicity.
- Hypothermia enhanced anti-neoplastic activity, especially with cisplatin, without compromising efficacy.
